Mathematical and statistical challenges in viral dynamic models: Ebola virus as a paradigm

10-28 June 2019

ICMS, The Bayes Centre, 47 Potterrow, Edinburgh EH8 9BT


Ebola virus is now one of the most feared pathogens worldwide, as recently demonstrated in the West African Ebola outbreak: between December 2013 and April 2016, the largest epidemic of Ebola virus disease (EVD) to date generated more than 28,000 cases and more than 11,000 deaths in the large, mobile populations of Guinea, Liberia, and Sierra Leone.

This ICMS strategic workshop will allow a multi-disciplinary team of scientists from different institutions to bring together expertise in virology, mathematics and statistics to address some of the current challenges in the field of viral dynamics. The different teams have never collaborated in a joint project, but recent DARPA-related activities have brought them together.

This workshop will establish a new and timely collaboration between researchers from four different overseas institutions (Ryerson, GVSU, LANL and Pasteur) with two UK institutions (Dstl and Leeds), as well as bridge disciplines outside of mathematics (i.e., physics, virology, and immunology). During the workshop, the exchange of expertise between theoretical and experimental participants will be facilitated, in order to conceptualise, plan and select the right combination of in vitro and in vivo experiments and experimental data (Challenge 1), statistical methods (Challenge 2), and intra-cellular mathematical models (Challenge 3) to study ebola virus EBOV replication kinetics and novel antiviral therapies, such as therapeutic interfering particles (TIPs). It is anticipated that work from this workshop research period will crystallise in the form of a joint grant application, an individual fellowship, as well as a collaborative publication, but at a minimum it will address a number of current challenges in the field of viral dynamics, such as the development of novel mathematical models of intra-cellular viral replication, competition and interference.

Invited participants include:
John Barr, University of Leeds
Catherine Beauchemin, Ryerson University
Veronika Bernhauerova Pasteur Institute
Jonathan Carruthers, University of Leeds
Benjamin Holder, Grand Valley State University
Gerard Jungman
Joshua Langwade, University of Leeds
Thomas Laws, Defence Science and Technology Laboratory
Laura Liao, Los Alamos National Laboratory
Martín López-García, University of Leeds
Grant Lythe, University of Leeds
Carmen Molina-París , University of Leeds
Sophie Smither, Defence Science and Technology Laboratory
Marco Vignuzzi, Pasteur Institute


Participation in this workshop is by invitation only. Invited participants will be contacted directly by the ICMS and their accommodation will be arranged for them in Edinburgh.

ICMS does NOT use third parties to arrange accommodation.  If you are approached by a third party (e.g. Business Travel Management) asking for booking details, please ignore.  If you have any concerns please contact ICMS.